Patrick Aisher

Danube Labs brings together CEBINA’s strength in scientific innovation and entrepreneurship, with Evotec’s industry-leading drug discovery and development expertise to accelerate academic life science research projects to mature projects ready for spin-out company formation, or out-licensing.

ReBio Pharma is a pre-clinical stage biotechnology company that has developed SiSu®, a novel, proprietary formulation technology that solves the safety and efficacy challenges other sustained release approaches have been unable to resolve. SiSu® is designed to steadily release effective levels of therapeutics within the eye while safely dissolving once drug release is completed, and can be tuned to the drug, indication, and duration of release required. ReBio Pharma is leveraging Sisu® to create a new franchise to transform the standard of care for the millions of patients around the world living with chronic eye disease. Discover more at www.rebiopharma.com

Established in Salzburg, Austria in 2016, NativeWaves delivers an engaging and immersive media experience to audiences around the world. Using cutting edge technology, NativeWaves has brought easy to use, advanced streaming solutions to the broadcast, e-sport and live entertainment industries. With easy access to reliable and perfectly synced multistream, video, audio and data encodings, broadcasters and event organisers can now offer audiences a best-in-class, personalised entertainment experience that will significantly enhance consumer enjoyment of live sports and events.

Corlieve Therapeutics, a fully owned subsidiary of UniQure, is a biotechnology company focused on bringing novel therapeutic options to patients with severe neurological disorders.

Araris Biotech AG is pioneering a novel linker technology for antibody-drug conjugates (ADCs.) Our linker platform enables the attachment of any payload to ‘off the shelf’ antibodies without the need of prior antibody engineering.

At LAVA, we are focused on applying our expertise in gamma-delta T-cell engagers (TCEs) to transform cancer therapy. We refer to our compounds as gamma-delta bispecific T-cell engagers, or gamma-delta bsTCEs. Our platform generates therapeutics that specifically activate a unique and relatively abundant effector gamma-delta T-cell subset called Vγ9Vδ2 (Vgamma9-Vdelta2) T-cells that have the ability to trigger activity of immune cells of both the innate and adaptive immune system. Our gamma-delta bsTCEs have demonstrated superior efficacy and safety profiles compared to other bsTCE approaches in preclinical studies and show preferential activity against tumor cells thereby potentially limiting toxicity in healthy tissue. To date, we are the only company developing bispecific gamma-delta T-cell engaging antibodies for the treatment of cancer. We are building a pipeline of gamma-delta bsTCEs that have applications in both solid and hematologic malignancies. Our lead program, LAVA-051, targets the tumor specific antigen CD1d, which can be overexpressed in multiple myeloma, chronic lymphocytic leukemia (CLL), and acute myeloid leukemia (AML), among other tumor types. LAVA-051 will enter a Phase I/IIa study in 1Q21.

ImCheck Therapeutics is designing and developing a new generation of immunotherapeutic antibodies targeting butyrophilins, a novel super-family of immunomodulators. As demonstrated by lead clinical-stage program ICT01, which has a mechanism of action to simultaneously modulate innate and adaptive immunity, ImCheck's “first-in-class” activating antibodies may be able to produce superior clinical results as compared to the first-generation of immune checkpoint inhibitors and, when used in combination, to overcome resistance to this group of agents. In addition, ImCheck’s antagonist antibodies are being evaluated as potential treatments for a range of autoimmune diseases. Co-founder of the Marseille Immunopole cluster, ImCheck benefits from support from Prof. Daniel Olive (INSERM, CNRS, Institut Paoli Calmettes, Aix-Marseille Université), a worldwide leader in γδ T cells and butyrophilins research; from the experience of an expert management team; and from the commitment of leading US and European investors.

Vico Therapeutics is committed to advancing RNA modulating therapies for patients with severe, genetic neurological disorders. Vico is initially targeting spinocerebellar ataxia types 3 and 1 and Huntington’s disease. Our VICOMER platform designs antisense oligonucleotides for various genetic defects by modulating or editing RNA. For more information, visit www.vicotx.com

ARTIRIA empowers catheters and guidewires. We develop cutting edge technologies to bring micromotion deep in the brain arteries, enabling a seamless navigation and stroke treatment. ARTIRIA comprises a passionate team willing to bring a new standard of care to stroke surgeons for the benefit of their patients.

Alentis Therapeutics, the Claudin-1 (CLDN1) company, is a clinical stage biotechnology company that focuses on developing first-in-class breakthrough treatments for CLDN1+ tumors and organ fibrosis.  Alentis is pioneering a novel approach to modify and reverse the course of disease progression targeting CLDN1, a previously unexploited target that plays a key role in the pathology of tumors and fibrotic diseases across multiple organs. Alentis is the only company developing potential treatments for solid cancers and fibrosis targeting CLDN1.  Alentis’ portfolio of anti-CLDN1 monoclonal antibodies includes a novel class of anti-cancer therapies designed to reprogram the tumor microenvironment (TME). The interplay between cancer cells and their surrounding microenvironment is highly promising for drug development as many cancers use the TME to build barriers that shield against immune system attacks. Alentis’ lead oncology asset, ALE.C04, is the first potential treatment to target CLDN1 in solid tumors. In addition, Alentis’ pipeline includes first-in-class therapies designed to modify and reverse the course of advanced organ fibrosis. ALE.F02, which is currently in Phase 1 clinical trials, is designed to target pathological overexpression of CLDN1 outside of the tight junction to resolve and reverse organ fibrosis and is being investigated for the treatment of fibrotic disease in the kidney, lung, and liver.  The company was founded in 2019 based on ground-breaking research in the laboratory of Prof. Thomas Baumert MD at the University of Strasbourg and the French National Institute of Health (Inserm).  Alentis is headquartered in Basel’s pharma-biotech hub in Switzerland with a subsidiary for R&D in Strasbourg, France. For more information, please visit us at www.alentis.ch or write to: info@alentis.ch

Motus GI Holdings, Inc. (NASDAQ: MOTS) is a medical technology company based in the U.S., with subsidiaries in the U.S. and Israel, dedicated to improving endoscopy outcomes, lowering costs and enhancing patient experiences. The Company is focused on the development and commercialization of the Pure-Vu® System, designed to improve the colonoscopy experience and assist in the early detection and prevention of colorectal cancer and other diseases of the rectum and colon. The Pure-Vu® System is a 510(k) U.S. Food and Drug Administration cleared medical device indicated to help facilitate the cleaning of a poorly prepared colon during the colonoscopy procedure. The device integrates with standard colonoscopes to enable cleaning during the procedure while preserving standard procedural workflow and techniques. The Pure-Vu® System has received CE mark approval in Europe.

Orchestra BioMed (Nasdaq: OBIO) is a biomedical innovation company accelerating high-impact technologies to patients through risk-reward sharing partnerships with leading medical device companies. Orchestra BioMed’s partnership-enabled business model focuses on forging strategic collaborations with leading medical device companies to drive successful global commercialization of products it develops. Under these collaborations, Orchestra BioMed advances its promising therapeutic solutions through late-stage clinical research and regulatory approvals, while its collaborators focus on leveraging their commercial expertise and existing infrastructure to bring these product candidates to global markets quickly and efficiently. Orchestra BioMed’s lead product candidate is atrioventricular interval modulation (AVIM) therapy (also known as BackBeat Cardiac Neuromodulation Therapy (CNT™)) for the treatment of hypertension, a significant risk factor for death worldwide. Orchestra BioMed is also developing Virtue® Sirolimus AngioInfusion™ Balloon (SAB) for the treatment of atherosclerotic artery disease, the leading cause of mortality worldwide. Orchestra BioMed has a strategic collaboration with Medtronic, one of the largest medical device companies in the world, for development and commercialization of AVIM therapy for the treatment of hypertension in pacemaker-indicated patients, and a strategic partnership with Terumo, a global leader in medical technology, for development and commercialization of Virtue SAB for the treatment of artery disease. Orchestra BioMed has additional product candidates and plans to potentially expand its product pipeline through acquisitions, strategic collaborations, licensing and organic development. For further information about Orchestra BioMed, please visit www.orchestrabiomed.com.

We’re DF Capital, a specialist savings and business finance bank built to serve the needs of individuals and businesses in the UK. From straightforward savings to practical finance solutions, our aim is to provide you with first-class customer service to help manage and grow your business or your savings. Founded in 2016 as a business finance lender, we began a mission to help businesses across the UK by providing them with flexible finance products that support the growth of their businesses. We were authorised as a bank in September 2020, which has enabled us to begin offering personal savings accounts to individual customers while continuing to maintain and develop the support we provide for UK businesses. Becoming a bank allows us to better support our existing customers and to widen that support to both new business finance and personal savings customers. Our team is built of knowledgeable and experienced specialists in savings and business finance. Delivering a trusted, reliable and customer focussed experience is at the heart of our business. We are proud of the strong, long-term relationships and reputation we have built over the years with our business finance customers and will deliver on those same principles to our personal savings customers. Financial Services Compensation Scheme Your eligible deposits with DF Capital are protected up to £85,000 by the Financial Services Compensation Scheme, the UK’s deposit protection scheme. Please click here for further information or visit https://www.fscs.org.uk/. DF Capital is authorised by the Prudential Regulation Authority (PRA) and regulated by the Financial Conduct Authority and PRA.

NovaGo’s fully human monoclonal antibodies have the potential to become a safe and effective treatment in central nervous system indications. NovaGo’s proprietary antibodies block the function of Nogo-A, one of the most potent and well-studied vascular and nerve growth inhibitors.

At CEBINA (Central European Biotech Incubator and Accelerator), we go beyond a traditional biotechnology incubator - uniquely supporting life science entrepreneurs and young biotech companies through all stages of early company development, transforming promising new ideas into fully formed biotech companies that are attractive for investment.

2cureX A/S is a biotech company with the mission to improve cancer treatment efficiency with the individual patient in focus. Our innovative scientists at 2cureX have used their exclusive knowledge and experiences to create our core technology - IndiTreat®an easy-to-use in-vitro test specialized in identifying and matching the individual cancer patient with the most effective medical treatment. In our clinical studies, we have shown that IndiTreat® can identify the right treatment; but more important for individualized cancer therapy is the therapy to which the patient is resistant. With a response rate of only 30% and months to pass before results are measurable using standard treatment regimen, IndiTreat® supports oncologists to find the perfect treatment for each individual patient. The IndiTreat® test allows medical doctors to test existing chemotherapeutic drugs using a small sample taken from the patients tumor, which is prepared as tumoroids or micro-tumors and their sensitivity tested for multiple treatment regimens and anti-cancer drug combinations. Within a few days, IndiTreat®identifies the drugs that made the tumor shrink and thereby increasing the number of patients responding, their life expectancy and quality of life. 2cureX A/S is located at Symbion, Fruebjergvej 3 2100 Copenhagen, Denmark and 2cureX GmbH is located at the University Medical Center Hamburg-Eppendorf (UKE), one of the largest hospitals in Northern Germany’s and renowned research facility. 2cureX is establishing laboratory facilities for conducting IndiTreat® testing in the UK and other European countries. Furthermore, we have successfully lead multiple collaborations with both commercial and academic partners.

Danube Labs brings together CEBINA’s strength in scientific innovation and entrepreneurship, with Evotec’s industry-leading drug discovery and development expertise to accelerate academic life science research projects to mature projects ready for spin-out company formation, or out-licensing.

ReBio Pharma is a pre-clinical stage biotechnology company that has developed SiSu®, a novel, proprietary formulation technology that solves the safety and efficacy challenges other sustained release approaches have been unable to resolve. SiSu® is designed to steadily release effective levels of therapeutics within the eye while safely dissolving once drug release is completed, and can be tuned to the drug, indication, and duration of release required. ReBio Pharma is leveraging Sisu® to create a new franchise to transform the standard of care for the millions of patients around the world living with chronic eye disease. Discover more at www.rebiopharma.com

CEBINA Bridge Capital has entered into a collaboration agreement – DANUBE LABS – with CEBINA GmbH and Evotec International GmbH for the purpose of identifying and supporting pharmaceutical drug discovery projects originating from universities, research institutes and other entities in Central and Eastern Europe with each project having specially agreed terms between the parties on the split of participation in any successful end product.

Danube BioVentures operates a series of venture capital funds geared towards pharmaceutical drug development and biomedical innovations emerging from early-stage projects.