Stephen Olmon

There are no words to describe the moment where you learn that your child’s life may be far shorter than you’d ever hoped or imagined. It feels impossible to know where to turn, and even take another step. Founded by a couple who found themselves in that very position, Abel Speaks was born out of this experience and exists to walk with parents who have chosen to carry a child with a life-limiting diagnosis. Every child’s life can be beautiful and meaningful, no matter the length. On this road where you never thought you’d find yourself, you are not alone. We are here to walk with you.

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Renibus is a clinical stage biopharmaceutical company dedicated to treating, improving and extending patients’ lives by developing breakthrough products to prevent disease progression, improve outcomes and protect against organ damage in cardiorenal diseases. The Company has developed a robust portfolio of products that activate multiple cytoprotective pathways, including organ protection via preconditioning. Renibus’ first-in-class lead program, RBT-1 (SnPP / FeS), is a potent inducer of Nrf2, IL-10, and ferritin. RBT-1 is currently in Phase 2 development in cardiac surgery and will soon enter a Phase 3 registration study for its lead indication to reduce the risk of postoperative complications following cardiothoracic surgery. RBT-2 (tetrahydrocurmin) is an antioxidant and anti-fibrotic drug that has been shown to reduce the risk of CKD progression in preclinical models and will be in IND enabling and clinical development in 2023. RBT-3 (FeS), a novel, low molecular weight iron nanoparticle, is one component of RBT-1 and is targeted at reducing the risk of cisplatin-induced nephrotoxicity and will be in clinical development in 2023. RBT-9 (SnPP), a potent anti-inflammatory and antioxidant drug with anti-viral properties, is one component of RBT-1. It has been investigated in a 42-patient Phase 2 RCT in COVID pneumonia as a monotherapy in hospitalized patients. RBT-9 reduced hospital length of stay by ~70%. Additional pre-clinical work is underway in NASH progression to help inform the clinical development strategy.

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There are no words to describe the moment where you learn that your child’s life may be far shorter than you’d ever hoped or imagined. It feels impossible to know where to turn, and even take another step. Founded by a couple who found themselves in that very position, Abel Speaks was born out of this experience and exists to walk with parents who have chosen to carry a child with a life-limiting diagnosis. Every child’s life can be beautiful and meaningful, no matter the length. On this road where you never thought you’d find yourself, you are not alone. We are here to walk with you.

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