Simeon George

Chief Executive Officer and Co-Founder at SR One Capital Management

📍 San Francisco Bay Area, United States🔄 Updated September 2026💼 4 investments📅 11 years investing🗓 Last invested Feb 2020
VC🌍 United States
4
Total investments
2
Early stage
2
Mid stage
0
Late stage
11y
Years active

Portfolio

4 investments · sorted by recency
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Mid stage
Late stage
Board Member
Feb 2020
We are a clinical-stage biotechnology company developing a new class of therapies based on its platform of GeneTAC™ gene targeted chimera small molecules. The company’s GeneTAC™ molecules are designed to either dial up or dial down the expression of a specific disease-causing gene to address the underlying cause of disease. Design’s lead program is focused on the treatment of Friedreich ataxia, followed by programs in Fuchs endothelial corneal dystrophy and myotonic dystrophy type-1 and discovery efforts for multiple other serious degenerative disorders caused by nucleotide repeat expansions. For more information, please visit designtx.com.
Board Member
May 2017
We officially combined with Bristol Myers Squibb to advance our precision oncology platform for patients. Visit www.bms.com to learn more about our work to produce the next generation of medicines for cancer patients. For more information on the acquisition, read our press release at: bit.ly/3Uccbu8
Board Member
Aug 2015
Nkarta is a clinical-stage biotechnology company advancing the development of allogeneic natural killer (NK) cell therapies for cancer. By combining its cell expansion and cryopreservation platform with proprietary cell engineering technologies, Nkarta is building a pipeline of cell therapy candidates generated by efficient manufacturing processes, and engineered to enhance tumor targeting and improve persistence for sustained activity in the body. For more information, please visit the company’s website at www.nkartatx.com.
Board Member
Apr 2015
CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts, and business offices in San Francisco, California and London, United Kingdom.
Experience · 6 entries
All (6)
Investments (4)
Board (4)
2020
Chief Executive Officer
Sep 2020
SR One Capital Management is a transatlantic biotech venture capital firm that seeks to partner with who we believe to be top entrepreneurs, scientists and investment partners in an effort to build elite biotechnology companies. SR One’s mission is to translate innovative technologies into potential next-generation medicines that benefit patients with significant unmet medical needs. SR One has offices in San Francisco, CA and London, UK. For more information, please visit www.srone.com.
Board Member
Feb 2020
We are a clinical-stage biotechnology company developing a new class of therapies based on its platform of GeneTAC™ gene targeted chimera small molecules. The company’s GeneTAC™ molecules are designed to either dial up or dial down the expression of a specific disease-causing gene to address the underlying cause of disease. Design’s lead program is focused on the treatment of Friedreich ataxia, followed by programs in Fuchs endothelial corneal dystrophy and myotonic dystrophy type-1 and discovery efforts for multiple other serious degenerative disorders caused by nucleotide repeat expansions. For more information, please visit designtx.com.
2017
Board Member
May 2017
We officially combined with Bristol Myers Squibb to advance our precision oncology platform for patients. Visit www.bms.com to learn more about our work to produce the next generation of medicines for cancer patients. For more information on the acquisition, read our press release at: bit.ly/3Uccbu8
2015
Board Member
Aug 2015
Nkarta is a clinical-stage biotechnology company advancing the development of allogeneic natural killer (NK) cell therapies for cancer. By combining its cell expansion and cryopreservation platform with proprietary cell engineering technologies, Nkarta is building a pipeline of cell therapy candidates generated by efficient manufacturing processes, and engineered to enhance tumor targeting and improve persistence for sustained activity in the body. For more information, please visit the company’s website at www.nkartatx.com.
Board Member
Apr 2015
CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts, and business offices in San Francisco, California and London, United Kingdom.
Show all 6 entries ↓
Investment activity
2015–2020 · 4 investments
201522017120201
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