Brian Mistler

Advisor

📍 United States🔄 Updated September 2026💼 16 investments📅 6 years investing🗓 Last invested Jan 2024
VC🌍 United States
16
Total investments
0
Early stage
3
Mid stage
6
Late stage
6y
Years active

Portfolio

12 investments · sorted by recency
All investments
Early stage
Mid stage
Late stage
Pre-IPO Investor
2024
As one of the fastest growing non-alcoholic beverage brands, Liquid Death uses comedy and entertainment to make health and sustainability 50 times more fun. We take low-calorie beverages and package them into infinitely recyclable cans that compete with the fun marketing of unhealthy brands across energy drinks, beer, and junk food. Our product lines include mountain water, soda-flavored sparkling water, iced tea, better-for-you energy, and more. A portion of Liquid Death’s proceeds goes to nonprofits who are helping fight plastic pollution and further our death to plastic bottles sustainability mission.
Series B Angel Investor
2024
Understand the Universe. We are a team of AI technologists and business leaders on a mission to build AI systems that can help humanity understand the world better. https://x.ai/careers
Angel Investor
2024
Cardiac Monitor
Early-stage Angel Investor
2024
TriAgenics is an oral health research and development firm that is working to eliminate the risk, disease, and pain associated with wisdom tooth extraction.
Early-stage Investor
2023
Solubag eliminates single-use plastics with disruptive and patented biodegradable raw material that dissolves in water. Since 2014, Solubag is committed to creating disruption and high-impact marketing and packaging products, both flexible and rigid. We partner with manufacturers to enable them to maintain existing operations and replace plastic production with our eco-friendly raw material. Solubag has received multiple awards and prizes for the disruption and the positive and direct impact that this solution has on the planet. Solubag founders and leadership are passionate about protecting our planet for future generations. Please visit our website to learn more.
late stageManufacturing
Early-stage Investor
2023
Everyone should get to drink great beer. That’s why we started exploring gluten-free alternatives to traditional brewing ingredients. Along the way, we discovered a huge spectrum of amazing flavors—we can’t wait to share them with you!
Angel Investor
2023
Gecko Robotics is the pioneer of AI + Robotics [AIR technology], transforming how the world builds, operates, and maintains its most critical infrastructure for a more reliable and sustainable future. Using fixed sensors and robots that climb, crawl, swim, and fly, we combine first-order data layers with the predictive power of AI into a single source of truth for the physical world. Cantilever® is our operating platform, powered by AIR technology, that empowers teams to achieve operational excellence through actionable data for immediate and long-term planning. Improve operations. Optimize capital outlay. Extend asset life. Thats our promise.
Pre-IPO Investor
2023
Neuralink is a neurotechnology company building a generalized input/output platform for the brain. Our work has the potential to restore autonomy to those with unmet medical needs and fundamentally transform how humans interact with the world. Our core technology is an implantable brain-computer interface with ultra-thin, flexible electrode threads placed precisely by a surgical robot, enabling high-bandwidth, bidirectional interaction with neural signals. We’ve received multiple FDA Breakthrough Device designations and are conducting clinical trials around the world. Trial participants are exploring how our implant could enhance their daily lives — controlling digital devices like computers and smartphones, operating physical devices like robotic arms and wheelchairs, and translating thought directly into speech and text. Developing brain-computer interfaces is an interdisciplinary challenge, and we’re looking for exceptional talent across engineering, science, and operations. Explore opportunities to contribute to our mission at neuralink.com/careers.
Angel Investor
2023
At Calendly, our vision is to take the work out of connecting with others so you can accomplish more. Our scheduling automation platform helps individuals, teams, and organizations globally automate meetings by removing the back and forth with scheduling. Our platform enables companies to close deals, hire candidates, build relationships, and grow their business — faster. More than 20 million users across 230 countries use Calendly to simplify meetings and collaborate more effectively and efficiently.
Early-stage Investor
2023
Membership club offering comprehensive amenities to Pickleball players. Play in perfect conditions on 12 indoor courts, plus 2 outdoor. • Private club experience in custom built dedicated indoor facility. • 12 indoor courts, 2 outdoor courts. • Play in perfect weather, any day, year-round. • Superior layered cushioned playing surface, with ideal bounce and play characteristics for Pickleball. Easy on your joints and body. • Many ways to meet new players at your skill level. Make new friends. • Reserve courts easily for your group with top notch online system. • Skill play, league play, tournaments. Plus, social events. • Private lessons, group lessons, clinics. From top coaches. • Pro Shop, observation deck, cafe, lockers & showers. • First location open now: Lakewood Ranch. 1300 Sarasota Center Blvd. Locations in development: Bonita Springs, Port St. Lucie, Fort Myers, Venice, Clearwater.
Angel Investor
2023
Inari is the SEEDesign™ company, using new breeding technology to push the boundaries of what is possible by designing nature-positive seeds for a more sustainable global food system. A combination of AI-powered predictive design and a pioneered multiplex gene editing toolbox enables us to unlock the full potential of seed and advance critical solutions with broad applications for growing more food with fewer resources.
Co-Founder & Investor
Jul 2020
Living with a serious illness can be difficult for patients and their families. VyncaCare is committed to empowering individuals, their loved ones, and their care teams with serious illness solutions that deliver care in their homes. By providing interdisciplinary care teams and advance care planning, we ensure that the uncertainty surrounding serious illness and complex health conditions are met in a compassionate way.
Experience · 23 entries
All (23)
Investments (15)
Founder (2)
2025
Research Project Associate
Apr 2025
The Canadian Institutes of Health Research (CIHR) is the Government of Canadas health research investment agency. CIHRs mission is to create new scientific knowledge and to enable its translation into improved health, more effective health services and products, and a strengthened health care system for Canadians. Composed of 13 Institutes, CIHR provides leadership and support to more than 13,700 health researchers and trainees across Canada. Terms and Conditions: http://www.cihr-irsc.gc.ca/e/14202.html
2024
Angel Investor
2024
Cytonics is a research and development company dedicated to discovering and developing therapeutics based on the protease inhibitor Alpha2 Macroglobulin (A2M). We are developing a number of A2M therapies with the goal of out-licensing the drugs to strategic partners at the key clinical value inflection points. We maximize the value of the drugs we discover by putting them in the hands of leading pharmaceutical companies with late-stage development, commercialization and marketing expertise. As a result of this strategy, we keep our organization focused with a strong financial position. We have discovered a unique “bio-marker” that can assist physicians in improving patient outcomes by pinpointing the source of orthopedic pain. We are also developing a range of therapeutic products for the treatment of painful osteoarthritis, back, and joint pain. Cytonics has a research lab located in Jupiter, FL with a team of scientists and PhD’s, working to discover and develop products for the treatment of musculoskeletal disease. Our Mission is to be the leader in diagnostic products for musculoskeletal disease, and to develop highly effective biotechnology based treatments for back and joint pain.
Pre-IPO Investor
2024
As one of the fastest growing non-alcoholic beverage brands, Liquid Death uses comedy and entertainment to make health and sustainability 50 times more fun. We take low-calorie beverages and package them into infinitely recyclable cans that compete with the fun marketing of unhealthy brands across energy drinks, beer, and junk food. Our product lines include mountain water, soda-flavored sparkling water, iced tea, better-for-you energy, and more. A portion of Liquid Death’s proceeds goes to nonprofits who are helping fight plastic pollution and further our death to plastic bottles sustainability mission.
Series B Angel Investor
2024
Understand the Universe. We are a team of AI technologists and business leaders on a mission to build AI systems that can help humanity understand the world better. https://x.ai/careers
Angel Investor
2024
Cardiac Monitor
Show all 23 entries ↓
Investment activity
2020–2024 · 16 investments
2020120231020245
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