Jeffrey Cleland

Syncromune is a privately held, clinical-stage biopharmaceutical company dedicated to the development of an in situ platform therapy optimized for metastatic solid tumor cancers that aims to achieve high response rates with potentially improved survival. The company is currently developing SYNC-T, a personalized in situ therapy that combines partial tumor oncolysis and a multi-target biologic drug. The novel SYNC-T combination approach is designed to target multiple mechanisms of cancer, promoting in situ immune activation while battling immunosuppression. The goal is to activate T cells, enabling the immune system to recognize and attack cancer throughout the body. The first two candidates, SV-101 and SV-102, are currently in Phase 1 trials.

Zylem Biosciences is a preclinical biotechnology startup, pioneering the development of targeted medicines by employing rational design inspired by nature. Our novel platform technology spans a deep pipeline of therapies applicable to diseases and conditions where lipid dysfunction plays a critical role, including cancer, skin disease, and eye disease. Visit our website to find out more.

Exicure, Inc. is an early-stage biotechnology company developing nucleic acid therapies targeting ribonucleic acid against validated targets to neurological disorders and hair loss. Our team includes a diverse scientific group with expertise in nucleic acid chemistry, drug development and neuroscience. Headquartered in Chicago, IL, Exicure conducts its discovery and development efforts in-house with a dedicated 30,000 sq. ft. facility, including rapid and automated high throughput nucleic acid synthesis and screening. Our platform for therapeutic nucleic acids demonstrates high potency, broad uptake, and prolonged efficacy in both in vitro and in vivo neurological models. The basis of our discovery approach harnesses our expertise in oligonucleotide chemistry to validated targets where we can screen thousands of oligonucleotides efficiently and validate top candidates in the appropriate cell and live animal models. Exicure's lead program is a non-opioid pain analgesic directed against the genetically validated target SCN9A (Nav1.7). Exicure has also identified several promising candidates across a series of CNS conditions with high unmet need including Huntington disease, Angelman syndrome, Batten disease, spinocerebellar ataxia, and sporadic amyotrophic lateral sclerosis.

Ashvattha Therapeutics is developing a new class of drugs that identify and treat diseased cells with unprecedented precision. Our proprietary hydroxyl dendrimer (HD) platform, exclusively licensed from Johns Hopkins University, allows for the creation of hydroxyl dendrimer therapeutics (HDTs), which link known small molecule drugs to HDs for selective delivery with sustained effect in diseased tissues. We believe this approach to precision medicine has the potential to change the standard of care across neurology, ophthalmology, hyperinflammatory diseases and neuro-oncology.

Elixirgen Therapeutics is a biotechnology company advancing its controllable self-replicating RNA technology to develop therapies for a broad spectrum of diseases, including rare diseases, aging-related disorders, and cancer. Elixirgen Therapeutics is located in the Science + Technology Park at Johns Hopkins in Baltimore.

Syncromune is a privately held, clinical-stage biopharmaceutical company dedicated to the development of an in situ platform therapy optimized for metastatic solid tumor cancers that aims to achieve high response rates with potentially improved survival. The company is currently developing SYNC-T, a personalized in situ therapy that combines partial tumor oncolysis and a multi-target biologic drug. The novel SYNC-T combination approach is designed to target multiple mechanisms of cancer, promoting in situ immune activation while battling immunosuppression. The goal is to activate T cells, enabling the immune system to recognize and attack cancer throughout the body. The first two candidates, SV-101 and SV-102, are currently in Phase 1 trials.

Zylem Biosciences is a preclinical biotechnology startup, pioneering the development of targeted medicines by employing rational design inspired by nature. Our novel platform technology spans a deep pipeline of therapies applicable to diseases and conditions where lipid dysfunction plays a critical role, including cancer, skin disease, and eye disease. Visit our website to find out more.