Guilhem De Vregille

Partner @XAnge

📍 Greater Paris Metropolitan Region, France🔄 Updated September 2026💼 16 investments📅 14 years investing🗓 Last invested Jan 2025
VC🌍 France
16
Total investments
5
Early stage
5
Mid stage
3
Late stage
14y
Years active

Portfolio

13 investments · sorted by recency
All investments
Early stage
Mid stage
Late stage
Investor & board member
Jan 2025
Vertical Compute is a European deep tech startup focused on developing a game-changing vertically integrated memory technology. The company aims to solve the memory bottleneck and to unlock the full potential of data-intensive applications. With a strong leadership team and a clear vision, Vertical Compute is set to revolutionize the future of computing.
Investor & board member
Jun 2022
Qubit Pharmaceuticals brings unparalleled accuracy and precision to drug discovery and design, using quantum physics to develop life-changing treatments for major diseases. No target is undruggable. Our proprietary technologies, the fruit of over 30 years of research, make it possible to develop novel drug candidates and innovative modes of action against targets previously considered too complex.
Investor & board member
Apr 2021
WE BELIEVE ⤵️ Front-end creation is an art when developers and designers work together to build extraordinary experiences. Its exciting but its HARD! They deserve better tools to focus on what matters and work collaboratively as a team. WHAT WE DO ✨ We build great software to empower front-end teams. https://divriots.com
Investor & board member
Jun 2020
Were hiring worldwide! https://wandercraft.welcomekit.co/ At Wandercraft, we believe movement is freedom. Since 2012, our mission has been simple but bold: restore mobility where it’s been lost, and expand what’s possible with robotics that move like people do. We see robotics as the ultimate partners—machines that can do what humans cannot, or should not, do. That means giving back the ability to walk to someone with a spinal cord injury, or stepping in on a factory floor where work is too heavy, repetitive, or hazardous. We pioneered the world’s first self-balancing exoskeleton—technology that doesn’t rely on crutches or walkers, but lets people stand and walk freely. Today, our work goes beyond healthcare. From rehabilitation centers to factory floors, and soon into homes and communities, we’re shaping a future where humans and robots move forward together. Our technology, powered by physical AI and 30+ patents, is life-tested in the most demanding environments: real people, real steps, real work. Meet our devices: Atalante X – A self-balancing exoskeleton enabling hundreds of patients with mobility disabilities to take over 1 million steps per month in 100+ leading hospitals and research centers worldwide. It is designed to promote upright posture, cardiovascular health, neuroplasticity, and—most importantly—upright independence. Eve – The world’s first self-balancing exoskeleton for personal use. Designed for daily life, Eve enables individuals with severe mobility impairments to walk hands-free at home and outdoors. Currently in U.S. clinical trials, Eve is expected to launch in 2026. Calvin-40 – Our first industrial humanoid robot. Autonomous and voice-operated, Calvin-40 is built to take on physically demanding or hazardous tasks in non-ergonomic environments. Based on the same platform as our exoskeletons, Calvin is already hard at work with Renault Group and more.
Investor & board member
Apr 2019
TreeFrog Therapeutics is a French-based biotech company aiming to unlock access to cell therapies for millions of patients. TreeFrog Therapeutics is developing a pipeline of therapeutic candidates using proprietary C-Stem technology, allowing for the mass production of induced pluripotent stem cells and their differentiation into ready-to-transplant microtissues with unprecedented scalability and cell quality. Bringing together over 150 biophysicists, cell biologists and bioproduction engineers, TreeFrog Therapeutics raised $82M in 2021 to advance its pipeline of stem cell-based therapies in the field of regenerative medicine with the lead program in Parkinsons Disease. In 2022, the company opened a technological hub in Boston, USA to drive the adoption of C-Stem and initiate co-development partnerships with leading academic, biotech and industry players in the field of cell therapy.
Investor & board member
Oct 2018
Manufacturing satellites for Earth Observation, Telecommunications and Technology Demonstrations, from 50 kg to 5000 kg. Proudly TRL9 since 2021. #BuildingOnHeritage
Investor & Board member
Feb 2018
Elum Energy is an energy & automation company providing ePowerControl technology : an Energy Management Systems (EMS) for renewable energy, storage, generators and other distributed resources. The controller is turn-key, simple to commission, compatible with major equipment brands on the market and made for complex electrical systems. A wide variety of sites from 100KW to 40MW ranging from factories, industrial & commercial buildings, utility scale power plants can benefit from our technology : ePowerControl integrates a local & remote SCADA system allowing for site equipments secure monitoring and control to get insight anywhere on portfolio status and KPIs. With projects in more than 40 countries Elum Energy delivers to project developers, energy companies and EPCs.
Investor & Board member
Oct 2017
Pollen Metrology is a pioneer and a worldwide leader in Holistic AI-driven process control software supplying IC Makers & Foundries, Process tool suppliers and Metrology/Inspection Tool suppliers with a suite of Software solutions to boost productivity from Lab to Fab and maximize high performance materials properties. Pollen Metrology unique technology is : 👉 focusing on both image-based and non image-based data analytics for metrology and inspection to accelerate the identification of the root cause of yield or materials processes degradation 👉 relying on integration of multi sensors heterogeneous data analytics, deep learning unsupervised and supervised approach and is hardware agnostic. 👉 providing a software development framework build for seamless integration to create infinite process control capabilities This software platform : 👉 accelerates time-to-market on new semiconductor processes (etching, deposition, lithography, etc.) 👉 creates Digital Platform Services to boost productivity. 👉 increases ROI of process, metrology and inspection hardware. The company operates internationally with Blue-Chip customers in North America, Asia and Europe Founded in 2014 in France, with offices and sales representatives in the US and Asia, the company has invested 100+ man-years in its product and technology.
Investor & board member
Sep 2015
Who’s your next client ? Sparklane is the first editor of predictive lead scoring solutions for the European B2B market. Accelerate your B2B Sales Process by focusing on the best prospects! Sparklane is an editor of a Predictive Lead Scoring Solution for B2B marketing and sales: Predict. Our mission is to leverage Artificial Intelligence to help you identify your market and steer you to the best opportunities. Predict automates your sales prospection : • Precisely defines your Ideal Client Profile • Automates the setup of your sales territory according to your criteria • Gives you direct access to the best prospects, scored according to their business context With Predict you can identify the right accounts to target : • Save time • Increase your conversion rate (up to 40%) • Shorten the sales life cycle Predict is connectable to the main CRM solutions : Salesforce, Microsoft Dynamics, … Contact us!
Investor & Board member
Dec 2013
MDoloris Medical Systems is a young innovative start-up (ISO 9001 and ISO 13485 certified) created in June 2010 to leverage more than 23 years of academic research conducted at the University Hospital of Lille. Our mission is to provide clinicians with the means to efficiently, continuously and non-invasively asses patient pain and comfort. The goal is to personalize pain therapy, in order to avoid known adverse effects of over- or underdosage of those drugs. Our technology is ideal when patients are unable to communicate, such as when they are under general anesthesia or unconscious in intensive care units, and also in children and newborn infants, dementia and Alzheimer's patients, and more. ------------------------------------------------------------------------------------------------------------------------------------------- Valorisant plus de 23 années de recherche académique, réalisées au sein du CHRU de Lille, Mdoloris Medical Systems est une jeune start-up (certifiée ISO 9001 et ISO 13485) innovante crée en Juin 2010. Notre mission consiste à fournir aux cliniciens des technologies permettant une évaluation fiable, continue et non-invasive de la douleur et du confort de leurs patients. L'objectif consiste à personnaliser la thérapeutique antidouleur afin d’éviter les effets indésirables des sur ou sous dosages de ces drogues. Nos technologies prennent tout leur sens lorsque les patients sont dans l’incapacité d’exprimer le ressenti douloureux (sous anesthésie générale, patients inconscients en réanimation, mais également les enfants, les patients atteints de démence, Alzheimer etc…).
Investor & Board Member
Jan 2013
Docea Power is the leading provider of virtual prototyping solutions to model, explore power and thermal behavior of electronic systems. Docea’s innovative solutions are able to simulate and validate power/thermal management strategies before actual Hardware and Software is available. Docea enables IP, SoC or Board designers to make the right energy-performance-cost trade-off and achieve their specifications. An overall power savings of up to 80% along with a reduction of integration and validation time by 75% can be reached by using Docea’s solutions. The company has its headquarters in the French Silicon Valley, near Grenoble, France, offices in San Jose, CA, in addition to application engineering and support in Japan and Korea. Its team draws on significant experience in both the semiconductor industry and EDA. The company has partnerships with several research centers and world's largest semiconductor companies and is recognized for its expertise and professionalism. The Docea software solutions have been used by leading semiconductor and electronic system companies all over the world to design products for which power and thermal performance are key metrics of success. By addressing the issues associated with battery autonomy, packaging, cooling costs, reliability, safety and energy efficient product certification, Docea products help go beyond the limits. Docea technology is key for designing competitive wireless applications like smartphones, tablets and IoT as well as home multimedia consumer, automotive, data networking, servers, telecom and medical systems. Whatever the complexity, whatever the system, whatever the application, Docea products gives the power of fast, secure and efficient handling of power and/or thermal issues at a higher level of abstraction.
Investor & Board Member
Jan 2013
Founded in 2010, Amoéba is an innovative industrial greentech specialised in the treatment of microbiological risk of natural resources. Our biosolutions are based on a unique micro-organism, the amoeba Willaertia magna C2c Maky. Thanks to our scientific, industrial and commercial know-how, we are able to provide biological alternatives for different applications and industries. 𝙊𝙐𝙍 𝙎𝙊𝙇𝙐𝙏𝙄𝙊𝙉𝙎 💄 Cosmetics : Our latest innovation offers anti-aging and UV protection properties. In October 2023, in vitro studies showed that this lysate stimulates cellular functions, activates wound healing genes, promotes hyaluronic acid synthesis, and enhances anti-infective immunity. These benefits were confirmed in a spring 2024 clinical study, with statistically significant results. Amoéba has successfully registered this ingredient on the INCI list, facilitating its commercialization and establishing it as a key player in innovative skincare solutions. 🌱 Biocontrol "AXPERA": Our second technology enables plant protection in agriculture and is based on the antifungal properties of the amoeba in its lysed (non-living) form. In 2022, the US Environmental Protection Agency (US EPA) has granted approval for the use of our solution in agriculture in the USA. In the same year, Austria issued a positive recommendation for the approval of our active substance in Europe. With this innovation, Amoéba contributes to an efficient, secure and more virtuous biological agriculture. 💧 Biocide "BIOMEBA": This historical application, initiated at the foundation of the company, enables the treatment of water in cooling towers and uses the amoeba Willaertia magna C2c Maky in its living form. In 2022, the US EPA has approved the use of our active substance in closed cooling systems in the USA, making our solution the first biological biocide approved for global industrial water treatment. Youtube 👉 @AmoebaNature X 👉 @AmoebaNature
Investor & Board member V3D
Oct 2012
EXPERT ON TELECOM DATA ANALYTICS V3D is 100% owned by SoftAtHome, a software company for the digital home, providing software products for connectivity, pay TV, Home Networking and the Smart Home deployed with major operators in over 20 million homes in 18 countries. Specialized in mobile and fixed network technologies, by collecting millions of data analytics, V3D product portfolio focuses on customer experience and carrier network service performance: The EQUAL ONE solution enables MNOs to perceive the network service quality the way subscribers do when browsing the web, using an application or watching a video. Compared to traditional network Quality of Service (QoS) systems (probes and other network-centric metrics), collecting data directly from the subscriber’s device allows MNO’s to change their perspective from a network-centric view to a subscriber-centric view because performance KPIs collected on their smartphones reflect the real-life experience of their customers. These KPI’s give a 360° view of the carrier’s QoE and strongly contribute to monitor the network performance and the customer experience. The MSCORE SOLUTION, a smart test server, provides real-time TCP/IP analysis during testing. mScore breaks down legacy barriers to QoS testing: available for both mobile and fixed-line broadband connection, from any mobile phone, web browser, set-top box or IoT equipment. mScore integrates seamlessly with existing test infrastructure for fast ROI, and its technology is easily scalable for large deployments. By combining EQual One monitoring agents with the powerful investigation capabilities of mScore, you will benefit from an end-to-end investigation solution! Are you experiencing unexpected, mysterious or malfunctioning behaviour in your services or networks? Contact us to learn more about how you may benefit from V3D's investigation tools & solutions for your network! Visit us at www.v3d.fr to find out more!
Experience · 17 entries
All (17)
Investments (16)
Board (16)
2025
Investor & board member
Jan 2025
Vertical Compute is a European deep tech startup focused on developing a game-changing vertically integrated memory technology. The company aims to solve the memory bottleneck and to unlock the full potential of data-intensive applications. With a strong leadership team and a clear vision, Vertical Compute is set to revolutionize the future of computing.
2022
Investor & board member
Jun 2022
Qubit Pharmaceuticals brings unparalleled accuracy and precision to drug discovery and design, using quantum physics to develop life-changing treatments for major diseases. No target is undruggable. Our proprietary technologies, the fruit of over 30 years of research, make it possible to develop novel drug candidates and innovative modes of action against targets previously considered too complex.
2021
Investor & board member
Apr 2021
WE BELIEVE ⤵️ Front-end creation is an art when developers and designers work together to build extraordinary experiences. Its exciting but its HARD! They deserve better tools to focus on what matters and work collaboratively as a team. WHAT WE DO ✨ We build great software to empower front-end teams. https://divriots.com
2020
Investor & board member
Jun 2020
Were hiring worldwide! https://wandercraft.welcomekit.co/ At Wandercraft, we believe movement is freedom. Since 2012, our mission has been simple but bold: restore mobility where it’s been lost, and expand what’s possible with robotics that move like people do. We see robotics as the ultimate partners—machines that can do what humans cannot, or should not, do. That means giving back the ability to walk to someone with a spinal cord injury, or stepping in on a factory floor where work is too heavy, repetitive, or hazardous. We pioneered the world’s first self-balancing exoskeleton—technology that doesn’t rely on crutches or walkers, but lets people stand and walk freely. Today, our work goes beyond healthcare. From rehabilitation centers to factory floors, and soon into homes and communities, we’re shaping a future where humans and robots move forward together. Our technology, powered by physical AI and 30+ patents, is life-tested in the most demanding environments: real people, real steps, real work. Meet our devices: Atalante X – A self-balancing exoskeleton enabling hundreds of patients with mobility disabilities to take over 1 million steps per month in 100+ leading hospitals and research centers worldwide. It is designed to promote upright posture, cardiovascular health, neuroplasticity, and—most importantly—upright independence. Eve – The world’s first self-balancing exoskeleton for personal use. Designed for daily life, Eve enables individuals with severe mobility impairments to walk hands-free at home and outdoors. Currently in U.S. clinical trials, Eve is expected to launch in 2026. Calvin-40 – Our first industrial humanoid robot. Autonomous and voice-operated, Calvin-40 is built to take on physically demanding or hazardous tasks in non-ergonomic environments. Based on the same platform as our exoskeletons, Calvin is already hard at work with Renault Group and more.
2019
Investor & board member
Apr 2019
TreeFrog Therapeutics is a French-based biotech company aiming to unlock access to cell therapies for millions of patients. TreeFrog Therapeutics is developing a pipeline of therapeutic candidates using proprietary C-Stem technology, allowing for the mass production of induced pluripotent stem cells and their differentiation into ready-to-transplant microtissues with unprecedented scalability and cell quality. Bringing together over 150 biophysicists, cell biologists and bioproduction engineers, TreeFrog Therapeutics raised $82M in 2021 to advance its pipeline of stem cell-based therapies in the field of regenerative medicine with the lead program in Parkinsons Disease. In 2022, the company opened a technological hub in Boston, USA to drive the adoption of C-Stem and initiate co-development partnerships with leading academic, biotech and industry players in the field of cell therapy.
Show all 17 entries ↓
Investment activity
2012–2025 · 16 investments
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