Emily Melton

Founder and Managing Partner at Threshold Ventures

📍 Portola Valley, California, United States🔄 Updated September 2026💼 19 investments📅 19 years investing🗓 Last invested Jan 2025
VC🌍 United States
19
Total investments
10
Early stage
7
Mid stage
2
Late stage
19y
Years active

Portfolio

19 investments · sorted by recency
All investments
Early stage
Mid stage
Late stage
Board Member
Jan 2025
VideaHealth is on a mission to transform dentistry through artificial intelligence. Rooted in AI research conducted at Harvard and MIT, VideaAI is an enterprise-grade AI dental assistant platform that increases patient trust and productivity and drives measurable business value with a scalable impact. With the largest and most diverse data set in the market, VideaHealth is the partner of choice for the nations leading DSOs - and is trusted by dentists, hygienists, and patients. Backed by leading venture capital firms Spark Capital, Zetta Venture Partners and Pillar VC, VideaHealth is headquartered in Boston with an office in New York.
Board Member
Jun 2024
Mendaera is building a new category of handheld robotics - designed to be deployed universally in healthcare. With our handheld robotic system, Focalist™, we aim to simplify and enhance ultrasound-guided needle procedures, a foundational procedure that underpins most patient journeys. At Mendaera, we believe these critical procedures deserve breakthrough innovation—so healthcare providers can do more, with greater confidence, for the patients who count on them. See Mendaera.com for Indications for Use.
Investor & Board Observer
May 2021
Transcarent is the One Place for Health and Care that makes it easy for people to access high-quality, affordable health and care. We are transforming healthcare with the WayFinding™ experience. It is the first time the power of generative AI has been placed into the hands of health consumers. Our Members Just Ask Transcarent™ to find trusted, personalized answers, take the next step for their health, and get on-demand care.
Board Member
Jan 2021
Calibrate is on a mission to change the way the world treats weight. As the leading clinician-guided and value-based outcomes model in obesity treatment, Calibrate combines medication with transformative behavior change to improve overall metabolic health, driving cost-effective, long-term weight loss results while reducing the total cost of care for employers and payers. Recognized by esteemed organizations, including the World Economic Forum’s Technology Pioneers, Fast Company’s World Changing Ideas, TIME’s Best Inventions, and the Employer Health Innovation Roundtable Traction Awards. Calibrate is backed by leading healthcare investors, including Madryn Asset Management, and Redesign Health.
Board Member
Aug 2020
Meet Brightline: a mental health benefit that provides families nationwide with virtual therapy, psychiatry, and coaching for kids and teens. When support is needed for behavioral and mental health challenges like anxiety, sleep troubles, ADHD, depression, or body image, think of Brightline as a trusted partner in parenting. Even better? Brightline is built specifically for families with fast access to personalized support, evidence-based care from specialized experts, and access to a one-stop digital platform to track progress, book appointments, & more.
Board Member
Mar 2020
Founded in 2017 by Carolyn Witte and Felicity Yost, Tia is bringing the new standard of care for women for women in NY, LA, SF and PHX. Blending in-person and virtual care services, Tia’s “Whole Woman, Whole Life” care model fuses gynecology, primary care, mental health and evidence-based wellness services to treat women comprehensively. By bringing collaborative, comprehensive, and compassionate care, Tia is raising the bar for women and empowering them to achieve optimal health, on their terms.
Board Observer
Oct 2019
Viz.ai is the leader in building and deploying AI-powered Care Pathways and helping doctors do their work. The Viz Platform is deployed in 2,000 hospitals across the United States and trusted by many of the leading life sciences companies. The platform uniquely combines real-time, multimodal clinical data with deep clinician engagement to detect disease earlier, coordinate care teams, and help ensure patients receive the right treatment faster. Viz.ai was the first company to be awarded CMS reimbursement for AI and is ranked the #1 Healthcare AI Platform by hospitals and health systems in the Black Book Research survey. For more information, visit Viz.ai.
Board Member
Jun 2018
Verge Genomics is a clinical-stage biotechnology company transforming drug discovery and development using artificial intelligence (AI) and human data. Verge is focused on developing therapeutics for complex diseases with high unmet need, using human genomics from patient disease tissues and machine learning. Verge has created a proprietary all-in-human CONVERGE® platform, featuring one of the field’s largest and most comprehensive databases of multi-omic patient data. The company is led by experienced computational biologists and drug developers who are successfully advancing clinical and preclinical therapeutic programs in various diseases, including ALS and Parkinson’s disease. Verge actively seeks a diverse applicant pool in order to build the strongest possible workforce. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Board Member
May 2018
Founded in 2017 by a team of experienced digital health and technology executives, OODA Health is transforming the administration of healthcare. Today, the US healthcare system wastes $400 billion every year on an outdated and broken claims adjudication process that creates friction and frustration for payers, providers and patients alike. Patients wrestle with surprise bills that arrive months after care is received and are impossible to understand. Providers suffer unexpected denials and delays for reimbursement, and chase patients for payment rather than focus on delivering care. Payers are locked in zero sum negotiations with providers, unable to advance care management goals. OODA Health is transforming the administrative experience in healthcare by enabling collaborative, real-time interactions between providers, members and payers. With the OODA Health solution, claims adjudication will be instantaneous, and providers will be paid upon patient checkout. Payers will assume responsibility for patient collections, guaranteeing immediate payment to the provider and relieving physicians from chasing patients for money. Care management strategies will be based on real-time patient risk models, rather than retrospective claim reviews. Critical interactions will occur at the point of care, rather than months after an encounter. We are a passionate, growing team looking for dedicated teammates to make a major impact on the healthcare system. We are committed to living our company values to provide a positive and dynamic working environment for our team members.
Board Member
Jul 2017
At BetterUp, we’re bringing the power of human transformation to individuals and workforces everywhere. Our mission? To help people everywhere pursue their lives with greater clarity, purpose, and passion. The BetterUp experience brings together world-class coaching, AI technology, and behavioral science experts to deliver change at scale — improving personal and organizational resilience, adaptability, well-being, and productivity. The results? Individual transformation meets organizational growth. Our proven effectiveness creates positive change for your business and your people. Using our proprietary algorithm and research, we create hyper-personalized experiences that motivate and inspire your people. Watch your organization transform with real-time data analytics and unparalleled human insights that create critical awareness into your workforce and demonstrate measurable results across 25 key leadership dimensions. Interested in joining our team? See open positions: https://www.betterup.com/about-us/careers
Board Member
Mar 2017
Imagen provides onsite, technology-enabled diagnostic solutions that allow primary care practices to maximize clinical outcomes, patient satisfaction, and financial results
Board Member
Nov 2016
The proven software platform for cell and gene therapy supply chain management. From the beginning, Vineti’s founders have understood the challenges that biotech and pharmaceutical innovators face in developing personalized therapies. Vineti’s Personalized Therapy Management (PTM®) platform is the essential enterprise software to drive and scale global personalized therapies, such as cell therapies, gene therapies, and cancer vaccines. PTM® connects the right patient to the right product, on time and on track.
Board Member
Aug 2016
Elation Health is the most trusted technology platform for high-value primary care. Since 2010, the company has delivered clinical-first solutions — built on a collaborative EHR platform — that help practices start, grow, communicate, and succeed in delivering the highest-quality personalized care to patients. Elation Health supports primary care clinicians in upholding the craft of medicine while thriving in an evolving healthcare landscape. Today, Elation Health serves 32,000 clinicians caring for millions of Americans.
Investor and Board Obserer
Mar 2015
Livongo is now a part of Teladoc Health. Teladoc Health is transforming the healthcare experience and empowering people everywhere to live healthier lives. Recognized as the world leader in whole person virtual care, Teladoc Health uses proprietary health signals and personalized interactions to drive better health outcomes across the full continuum of care, at every stage in a person’s health journey. In more than 175 countries and ranked Best in KLAS for Virtual Care Platforms in 2020, Teladoc Health leverages more than a decade of expertise and data-driven insights to meet the growing virtual care needs of consumers and healthcare professionals. For more information, please visit www.teladochealth.com or follow @TeladocHealth on Twitter.
Board Memberr
Aug 2014
Wellframe strategically partners with health plans nationwide to reimagine the relationship between plans and members. Our digital health management solutions for care management and advocacy enable a level of care and support that empowers people and organizations to achieve their best. By combining innovative solutions, strategic partnership, and passionate conviction, Wellframe creates measurable impact on lives, at scale.
Show all 19 investments ↓
Experience · 22 entries
All (22)
Investments (19)
Founder (1)
Board (15)
2025
Board Member
Jan 2025
VideaHealth is on a mission to transform dentistry through artificial intelligence. Rooted in AI research conducted at Harvard and MIT, VideaAI is an enterprise-grade AI dental assistant platform that increases patient trust and productivity and drives measurable business value with a scalable impact. With the largest and most diverse data set in the market, VideaHealth is the partner of choice for the nations leading DSOs - and is trusted by dentists, hygienists, and patients. Backed by leading venture capital firms Spark Capital, Zetta Venture Partners and Pillar VC, VideaHealth is headquartered in Boston with an office in New York.
2024
Board Member
Jun 2024
Mendaera is building a new category of handheld robotics - designed to be deployed universally in healthcare. With our handheld robotic system, Focalist™, we aim to simplify and enhance ultrasound-guided needle procedures, a foundational procedure that underpins most patient journeys. At Mendaera, we believe these critical procedures deserve breakthrough innovation—so healthcare providers can do more, with greater confidence, for the patients who count on them. See Mendaera.com for Indications for Use.
2021
Investor & Board Observer
May 2021
Transcarent is the One Place for Health and Care that makes it easy for people to access high-quality, affordable health and care. We are transforming healthcare with the WayFinding™ experience. It is the first time the power of generative AI has been placed into the hands of health consumers. Our Members Just Ask Transcarent™ to find trusted, personalized answers, take the next step for their health, and get on-demand care.
Board Member
Jan 2021
Calibrate is on a mission to change the way the world treats weight. As the leading clinician-guided and value-based outcomes model in obesity treatment, Calibrate combines medication with transformative behavior change to improve overall metabolic health, driving cost-effective, long-term weight loss results while reducing the total cost of care for employers and payers. Recognized by esteemed organizations, including the World Economic Forum’s Technology Pioneers, Fast Company’s World Changing Ideas, TIME’s Best Inventions, and the Employer Health Innovation Roundtable Traction Awards. Calibrate is backed by leading healthcare investors, including Madryn Asset Management, and Redesign Health.
2020
Board Member
Aug 2020
Meet Brightline: a mental health benefit that provides families nationwide with virtual therapy, psychiatry, and coaching for kids and teens. When support is needed for behavioral and mental health challenges like anxiety, sleep troubles, ADHD, depression, or body image, think of Brightline as a trusted partner in parenting. Even better? Brightline is built specifically for families with fast access to personalized support, evidence-based care from specialized experts, and access to a one-stop digital platform to track progress, book appointments, & more.
Show all 22 entries ↓
Investment activity
2007–2025 · 19 investments
20071201112013220141201512016220172201822019120202202122024120251
Recent (last 2 years)Earlier