Donald R. Dye

Shadow Entrepreneur and Investment Manager, Capitalizing and Derisking Early-stage Ventures into $1BN+ Liquidity Exits; Orchestrates Capital, Governance & Strategy across Real Estate, Life Sciences, AI, Global Markets

📍 United States🔄 Updated September 2026💼 9 investments📅 9 years investing🗓 Last invested Jun 2024
VC🌍 United States
9
Total investments
2
Early stage
1
Mid stage
3
Late stage
9y
Years active

Portfolio

9 investments · sorted by recency
All investments
Early stage
Mid stage
Late stage
Founding Investor
Jun 2024
Investor
Mar 2023
CoreWeave is the Essential Cloud for AI
Investor and Advisor
Aug 2022
Koning Corporation develops and manufactures advanced medical imaging systems for breast cancer detection using cone-beam computed tomography technology. This revolutionary technology provides true 3D images for early breast cancer detection, providing a significantly more accurate and effective test than mammography and tomosynthesis. Koning's vision is to fundamentally change breast cancer is detected and diagnosed, with earlier detection, increased patient comfort and lower costs. We believe our Koning Breast CT will dramatically improve the way clinicians visualize and evaluate breast tissue. We believe that the power, versatility and lower cost of Koning Breast CT will serve as a viable substitute for many traditional imaging applications. Our hope is to be able to improve survival rates and outcomes for millions of patients. Koning Corporation's core technologies are protected by over 80 patents globally, and has received regulatory approval in the US (FDA), Europe (CE-Mark), China (CFDA), Australia (TPG), and Canada (Health Canada). Koning has been the beneficiary of over $17 M in venture funding and over $20 M in government grants to bring this exciting technology to market. Future versions of our technology are expected to optimize early disease detection, diagnosis, intervention and treatment in numerous areas of the body.
Early Investor and Advsor
Aug 2021
In December 2022, Snackable joined Amazon to continue innovating and exploring new experiences on behalf of Amazon Music’s podcast customers. For more information, see: https://music.amazon.com/
Board Member
Jul 2021
Luciole is a start-up biotechnology company discovering and developing small molecule activators of OGG1, to accelerate the repair of oxidative damage to mitochondrial DNA. Luciole Pharmaceuticals is developing first-in-class agents as disease-modifying therapeutics for diseases of aging. Our efforts have the potential to lead to the discovery of a novel, safe, and very effective oral medicine for obesity and metabolic syndrome, fatty liver disease and neurodegeneration, which will improve patients’ quality-of-life and increase their life expectancy.
Early Investor
Apr 2021
Akston Biosciences Corporation invents, develops, and manufactures breakthrough protein therapeutics for Companion Animal Health. Akston uses its Ambifect™ Fc-fusion platform to design its own novel candidates and operates a multi-kilogram-scale cGMP biologics clean-room factory dedicated to Animal Health therapeutic production. The company also provides Contract Development and Manufacturing Organization (CDMO) services for other Animal Health companies.
late stageBiotechnology
Early Investor
Apr 2021
Tvardi Therapeutics is a clinical stage, private biotechnology company developing a new class of breakthrough medicines for diverse cancers, chronic inflammatory diseases and fibrotic diseases. Founded in 2017 and based in Houston, Texas, the company is led by experienced entrepreneurs, innovative scientists and dedicated physicians. Tvardi is focused on the development of inhibitors of STAT3, a key signaling molecule positioned at the intersection of many pathways controlling gene networks integral to the survival and immune sequestration of cancer cells as well as to the pathogenesis of many inflammatory and fibrotic conditions. Tvardi is conducting a first-in-human Phase Ia dose-escalating study to determine safety and dosing for follow-on studies for its lead compound, TTI-101. Collectively, the societal and economic impact of STAT3-dependent disease is significant. Tvardi is highly motivated to develop safe and effective small molecule inhibitors of STAT3 for use across numerous diseases.
Early Investor
May 2017
The Etiometry Platform is the only critical care software solution that reveals deep insights into patient physiology, helping critical care teams deliver standardized and individualized care – and provides the ability to automate care escalation and de-escalation decisions. It is designed to facilitate the use of all available data to support the anticipation and management of the dynamic condition of patients requiring intensive care. To learn more, visit www.etiometry.com. About Etiometry Founded in 2010, Etiometry is the leader in clinical decision-support software designed to help clinicians in the intensive care setting make data-based decisions regarding their patients’ care and treatment. The company’s technologies provide valuable clinical insight and analysis to support early recognition of subtle changes in patients’ conditions to avoid complications and speed recovery. Etiometry has nine FDA clearances and four Health Canada approvals and CE markings. With roots in pediatric ICUs, Etiometry is utilized by some of the world’s top academic medical centers as well as leading children’s hospitals ranked by US News and World Report and Newsweek.  Etiometry is committed to improving patient outcomes, increasing clinical efficiency, and lowering the cost of care through the more effective use of data.
Seed Investor and Advisor
Mar 2017
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Experience · 15 entries
All (15)
Investments (9)
Founder (2)
Board (1)
2024
Founding Investor
Jun 2024
2023
Investor
Mar 2023
CoreWeave is the Essential Cloud for AI
2022
Managing Partner
Oct 2022
Poder Partners is a vehicle which invests partner and investor capital in technologies which the partners view as transformational in the improvement of health, the environment and overall human welfare.
Investor and Advisor
Aug 2022
Koning Corporation develops and manufactures advanced medical imaging systems for breast cancer detection using cone-beam computed tomography technology. This revolutionary technology provides true 3D images for early breast cancer detection, providing a significantly more accurate and effective test than mammography and tomosynthesis. Koning's vision is to fundamentally change breast cancer is detected and diagnosed, with earlier detection, increased patient comfort and lower costs. We believe our Koning Breast CT will dramatically improve the way clinicians visualize and evaluate breast tissue. We believe that the power, versatility and lower cost of Koning Breast CT will serve as a viable substitute for many traditional imaging applications. Our hope is to be able to improve survival rates and outcomes for millions of patients. Koning Corporation's core technologies are protected by over 80 patents globally, and has received regulatory approval in the US (FDA), Europe (CE-Mark), China (CFDA), Australia (TPG), and Canada (Health Canada). Koning has been the beneficiary of over $17 M in venture funding and over $20 M in government grants to bring this exciting technology to market. Future versions of our technology are expected to optimize early disease detection, diagnosis, intervention and treatment in numerous areas of the body.
2021
Early Investor and Advsor
Aug 2021
In December 2022, Snackable joined Amazon to continue innovating and exploring new experiences on behalf of Amazon Music’s podcast customers. For more information, see: https://music.amazon.com/
Show all 15 entries ↓
Investment activity
2017–2024 · 9 investments
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Recent (last 2 years)Earlier