Alessandra Di Bacco

At EvolveImmune, we harness our “Immunology First” approach to create first-in-category cancer medicines to transform the lives of patients by delivering superior, long-term outcomes compared to current anti-cancer therapies. We are pioneers who rapidly translate discoveries into innovations and innovations into differentiated therapeutic solutions, to address the most significant unmet medical needs in oncology. We are based in Branford, CT and Farmington, CT.

We are a clinical-stage biotechnology company reimagining cell therapy through the development of innovative immunotherapies.

Ribon is a clinical-stage biotechnology company dedicated to the discovery and development of first-in-class small molecule inhibitors to block the fundamental ability of cancer cells to survive under stress.

At EvolveImmune, we harness our “Immunology First” approach to create first-in-category cancer medicines to transform the lives of patients by delivering superior, long-term outcomes compared to current anti-cancer therapies. We are pioneers who rapidly translate discoveries into innovations and innovations into differentiated therapeutic solutions, to address the most significant unmet medical needs in oncology. We are based in Branford, CT and Farmington, CT.

We are a clinical-stage biotechnology company reimagining cell therapy through the development of innovative immunotherapies.

“What if you could test the efficacy of multiple new cancer drugs in a patient without harmful side effects?” We asked this question when we started Presage to address a fundamental issue that hampers development of new cancer drugs. The issue as we see it is that new drugs are tested in laboratory models of cancer that simply do not accurately represent the complexity of the human tumor microenvironment and therefore do not reliably predict patient benefit in the clinic. As a result, drugs that exhibit outstanding performance in preclinical models of cancer more often than not, fail to provide benefit to patients when these same agents are tested in clinical trials. Its hard to deny this issue. The composite success rate for cancer drug candidates entering trials is a dismal 8%. This overwhelming percentage of clinical failures comes at tremendous cost to drug developers ($100s of millions to billions), and most importantly to patients in need of new therapy options. We can do better. Presage is addressing this issue with CIVO technology. CIVO enables, for the first time, simultaneous evaluation and comparison of multiple anti-cancer drugs, drug candidates, and drug combinations directly in a patient’s tumor, without toxicities associated with typical clinical drug exposures. This is done via a new way to approach Phase 0 clinical trials. Presage has established feasibility of CIVO in the clinic, a dedicated engineering and clinical operations team, a clear regulatory path, and a network of CIVO-trained clinical sites to execute on Phase 0 collaborations with biopharma partners. Presage has also established Phase 0 collaborations with marquee cancer drug development companies including Takeda, Celgene and Bristol-Myers Squibb. Our ultimate goal is to improve early drug evaluation and substantially increase the success rate of new drugs for cancer patients.

Ribon is a clinical-stage biotechnology company dedicated to the discovery and development of first-in-class small molecule inhibitors to block the fundamental ability of cancer cells to survive under stress.

Takeda Oncology, the Global Oncology Business Unit of Takeda Pharmaceutical Company Limited, is structured to ensure a tight connection from research to development to commercialization and rapidly meet the needs of the cancer community, optimizing our ability to bring transformative medicines to market. Built on a legacy foundation and structured for agility, our leaders have proven experience to drive future growth. We’ve demonstrated leadership in the treatment of hematologic cancers and solid tumors, and we’re now leveraging that expertise to advance cutting-edge science through multiple platforms, partnerships and therapeutic approaches. We are focused on collaborating with leading scientific teams around the globe to accelerate remarkable innovation, including by leveraging the power of innate immunity to enhance and broaden the impact of immunotherapy. We complement our deep in-house expertise with a network of symbiotic external partnerships to unlock the most promising science wherever it emerges. We fuel our relationships with academic, biotechnology and pharmaceutical partners with mutual respect, shared knowledge, scientific rigor and agility to find the best way to attack cancer. Takeda Oncology: We aspire to cure cancer, with inspiration from patients and innovation from everywhere. For more information, visit www.takedaoncology.com. If you are interested in learning more about current career opportunities, please visit the Takeda Pharmaceuticals Career Page. Review our social media community guidelines: https://www.takedaoncology.com/social-media-policy/